Double Butyrate | Digestive Tract, Brain & Nervous System Support; Epigenetic Reset


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  • Enhances gut health and supports the nervous system
  • Reduces inflammation
  • Aids in improving gut barrier function while nurturing a balanced microbiome and reducing intestinal inflammation
  • Enhances immune response
  • Supports healthy gut-brain axis health
  • Helps prevent fatigue, brain fog, and related conditions
  • Vital for epigenetic regulation
  • Ideal for enhancing cognitive function in children and adults

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What is Double Butyrate?

Double Butyrate is a cutting-edge supplement designed to support gut health, brain function, and now, cellular health at an epigenetic level. This unique formulation combines two types of butyrate with additional natural ingredients, each selected for its specific health benefits. We used low odor butyrate, which has no detectable butyrate odor.



Double Butyrate – A Keystone For Gut Health In A Modern World
In an era where the hustle of modern life seems inescapable, our health, especially gut health, pays a steep price. Environmental toxins, stress, poor dietary choices, and a lifestyle far removed from those of our ancestors have led to a surge in digestive issues, autoimmune diseases, mood disorders, and a decline in overall well-being.

The digestive tract, home to 70-80% of our immune system and a significant portion of our brain’s hormones, is under constant assault. Recognizing this critical issue, Return Healthy has meticulously developed Double Butyrate, a cutting-edge supplement designed to fortify gut health and foster a robust immune system, mirroring the vibrant health of traditionally living peoples, such as the Hadza tribe.

Understanding The Modern Plight
Modern lifestyles have led to a drastic reduction in microbiome diversity, a key factor in numerous contemporary illnesses. The convenience of processed foods, exposure to pesticides, and the stress of daily life contribute to this decline, distancing us from the robust health experienced by those who lead a more traditional and natural lifestyle. Double Butyrate steps in as a beacon of hope, aiming to reverse these effects by supporting the gut-brain, gut-immune, and gut-heart health axes.

The Power of Double Butyrate
Our unique formulation combines the benefits of tributyrin, calcium butyrate, Shilajit, and aloe vera 200:1 with the probiotic support of Bacillus coagulans, Lacticaseibacillus rhamnosus GG, and Saccharomyces boulardii. This powerful blend is designed to nourish the gut microbiome, promote a balanced inflammatory response, and support overall wellness without the common side effects associated with butyrate supplementation.


  • Low-Odor Butyrate: Delivers the critical benefits of butyrate, a short-chain fatty acid essential for gut health, without the off-putting smell
  • Probiotic Support: Features a blend of probiotics including Bacillus coagulans, Lacticaseibacillus rhamnosus GG, and Saccharomyces boulardii, chosen for their immune and histamine-friendly properties
  • Gut-Brain Connection: Enhances communication between the gut and brain, promoting mental and emotional well-being
  • Immune and Inflammatory Support: Aids in managing inflammatory processes and balancing the immune response, crucial for those suffering from MCAS (Mast Cell Activation Syndrome)
  • Gut-Heart Health: Supports cardiovascular health through its beneficial effects on gut health
  • Antioxidant-Rich: Contains Shilajit and aloe vera for their potent antioxidant properties, offering cellular protection against oxidative stress
  • Digestive Comfort: Specially crafted to minimize discomforts like gas and bloating, ensuring a smooth and beneficial gut health regimen

Embracing Tradition for Modern Wellness
By reintroducing the vital components of butyrate and a carefully selected probiotic blend, Double Butyrate aims to restore the natural balance of our gut microbiome. This not only aids in digestion but also plays a pivotal role in our overall health, drawing inspiration from the disease-resilient and diverse microbiomes of traditional peoples.

In essence, Double Butyrate is more than just a supplement; it’s a bridge to the past, reconnecting our modern lifestyles with the ancestral wisdom of living in harmony with nature. It represents a critical step towards reclaiming our health, emphasizing the undeniable link between a healthy gut and a healthy life.

As we continue to navigate the complexities of modern living, integrating Double Butyrate into our daily routine offers a simple yet profound way to support our body’s natural defenses, enhance our mental clarity, and embrace a life of vitality and wellness. Return Healthy invites you to experience the transformative power of Double Butyrate, a testament to our commitment to your health and well-being in the modern world.



What are the benefits of Double Butyrate?

  • Enhances gut health and supports the nervous system
  • Reduces inflammation
  • Aids in improving gut barrier function while nurturing a balanced microbiome and reducing intestinal inflammation
  • Reduces intestinal inflammation
  • Enhances immune response
  • Supports healthy gut-brain axis health
  • Helps prevent fatigue, brain fog, and related conditions
  • Vital for epigenetic regulation
  • Ideal for enhancing cognitive function in children and adults

Dual-Action Butyrate
Calcium Butyrate: Enhances gut health and supports the nervous system. It’s involved in reducing inflammation and is recognized for its potential in neurological conditions, including FDA approval for ALS treatment with the sodium phenylbutyrate form of butyrate.

Tributyrin: Aids in improving gut barrier function and nurturing a balanced microbiome, the key to reducing intestinal inflammation.

Shilajit for Barrier and Mitochondrial Function
Contains Shilajit, rich in humic and fulvic acids, aiding in gut barrier support and mitochondrial energy production.

Aloe Vera for Digestive Health
Aloe vera concentrate soothes the digestive system, enhances barrier function, and supports digestive immunity.

Probiotic Benefits
Bacillus Coagulans & Lacticaseibacillus Rhamnosus GG: These probiotics are celebrated for improving gastrointestinal function, enhancing immune response, and contributing to overall digestive health.

Saccharomyces Boulardii: A non-colonizing yeast probiotic beneficial for gut flora balance and managing digestive disorders.

Gut-Brain Axis
Emphasizes the crucial connection between a healthy gut and brain health, influencing mood, cognitive abilities, and neurodegenerative disease risk.

Robust Digestive Barrier
A strong gut barrier helps prevent systemic inflammation, fatigue, brain fog, and related conditions. “Double Butyrate” is designed to strengthen this barrier.

Epigenetic Impact of Butyrate
Histone Deacetylase Inhibitor: Butyrate acts as a histone deacetylase inhibitor, playing a vital role in epigenetic regulation. This action helps reset and reboot cellular functions, steering them away from a cell danger response towards a more natural expression of healthful genetic potential.

Transforming Health Histories
This epigenetic modulation can shift health trajectories from being non-responsive to lifestyle and dietary changes to unlocking the full genetic potential for health. It mirrors the robust, resilient health of our ancestors, enabling a return to natural, optimal health states over time.

Benefits Across All Ages: Ideal for enhancing cognitive function in children and adults, addressing conditions like ADD, ADHD, and autism spectrum disorders, and supporting cognitive health in aging populations.


What’s inside Double Butyrate?

Ingredients: Tributyrin (as Butyragen) 200 mg, Calcium Butyrate 2000 mg, Shilajit Extract 20% Fulvic Acid 80 mg, Aloe Vera 200:1  80 mg, Bacillus coagulans 2.5 billion CFU, Lacticaseibacillus rhamnosus GG 2.5 billion CFU, Saccharomyces boulardi 0.4 billion CFU


How do I take Double Butyrate?

Take 2 capsules twice per day with or without food, or as directed by your health care practitioner.


FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Please consult your health care practitioner before starting any dietary supplement or herbal regimen.

Additional information

Weight 0.56 oz
Dimensions 6 × 3 × 3 in




































We are working on updating our Double Butyrate FAQ at this time. Please contact us at sales@returnhealthy.com and we will happily answer any questions you have about our Double Butyrate product.

What's Inside

Tributyrin, often highlighted for its potential health benefits, is a triglyceride that naturally occurs in small amounts in butter and other dietary sources. Its significance in health and nutrition has been explored in various contexts, particularly for its role in supporting gut health and potential therapeutic applications. Here are a few detailed points about Tributyrin: Source and Composition: Tributyrin is composed of butyric acid and glycerol. It serves as a source of butyrate, a short-chain fatty acid (SCFA) that is a primary energy source for colonocytes (the cells lining the colon) and plays a critical role in maintaining intestinal barrier function and health. Gut Health Benefits: By delivering butyrate directly to the colon, Tributyrin can promote a healthy intestinal environment, support the growth of beneficial bacteria, and strengthen the intestinal barrier. This can help in the management of conditions such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Anti-inflammatory Properties: Tributyrin has been shown to possess anti-inflammatory properties, potentially reducing inflammation in the gut and other parts of the body. This makes it a compound of interest for addressing chronic inflammation-related conditions. Immune System Modulation: Through its effects on the gut, Tributyrin can also influence the immune system, promoting a balance between immune response and tolerance. This is crucial for preventing excessive immune reactions and supporting overall immune health. Enhanced Absorption: Compared to butyric acid alone, Tributyrin is less odorous and more palatable, making it easier to include in supplements and functional foods. Its structure allows it to reach the colon where it can be metabolized to release butyrate, making it an effective means of delivering this beneficial SCFA to the body.
Calcium butyrate is a calcium salt derived from butyric acid, a short-chain fatty acid primarily found in the gut as a product of dietary fiber fermentation by gut microbiota. It’s recognized for its role in maintaining intestinal health and supporting the gut microbiome. We use a very low odor butyrate, which is hardly noticeable. Gut Health Benefits: It acts as a primary energy source for colonocytes (cells of the colon), promoting the integrity of the gut lining, supporting healthy gut flora, and contributing to a healthy gastrointestinal environment. This can help in reducing inflammation and enhancing the absorption of minerals and nutrients. Immune System Support: Calcium butyrate has been shown to have anti-inflammatory properties, which can support the immune system. It helps in modulating the immune response, potentially reducing the risk of gut-related and systemic inflammatory conditions. Potential in Reducing the Risk of Colon Cancer: Research suggests that butyrate can induce apoptosis (programmed cell death) in colon cancer cells, which might reduce the risk of colon cancer. It’s believed to play a role in the prevention of cancerous cell growth in the colon. Bone Health: As a source of calcium, it contributes to the maintenance of bone density and strength. Calcium is vital for bone health, nerve transmission, muscle function, and blood clotting. Support for Metabolic Health: There is evidence to suggest that butyrate can improve insulin sensitivity and regulate blood sugar levels, making it beneficial for metabolic health. Odor and Taste Considerations: While butyrate compounds are known for their unpleasant smell and taste, calcium butyrate is often used in encapsulated forms in supplements to minimize these characteristics, making it more palatable for consumers. Butyrate as an HDAC Inhibitor and its Epigenetic Impact: Butyrate acts as a potent inhibitor of histone deacetylases (HDACs). This inhibition plays a crucial role in epigenetic regulation, offering a “reset” or “reboot” of epigenetic marks on histones. This action allows for the increased accessibility of transcriptional machinery to previously silenced gene regions, potentially aiding in the recovery from chronic illnesses. By modifying the epigenetic landscape, butyrate can influence gene expression in a way that supports the healing processes, immune modulation, and inflammation reduction. This mechanism highlights the potential of butyrate and its derivatives, like tributyrin and calcium butyrate, in therapeutic strategies aimed at addressing the underlying epigenetic factors of chronic diseases, offering a natural avenue to potentially undo the effects of chronic, fatigue-associated, and environmentally acquired illnesses.
Shilajit is a natural substance found in the mountainous regions of the Himalayas and other parts of the world. It is formed over centuries from the slow decomposition of plants. This particular form of Shilajit is standardized to contain 20% fulvic acid, ensuring a consistent and potent dose in each serving. Fulvic acid is one of the primary bioactive compounds in Shilajit, known for its numerous health benefits. Fulvic Acid Benefits: Fulvic acid is a powerful antioxidant and anti-inflammatory agent. It helps in the transportation of nutrients into cells and enhances the bioavailability of other nutrients and supplements. Fulvic acid can support a healthy immune system, improve gut health, and enhance energy levels by improving mitochondrial function. Role of Humic Acid: Alongside fulvic acid, Shilajit also contains humic acid, which contributes to its therapeutic properties. Humic acid is beneficial for its detoxifying qualities. It binds to toxins and heavy metals, facilitating their removal from the body. This detoxification can support overall health and well-being, especially in environments burdened by pollutants and toxins. Epigenetic Influence and Chronic Illness Recovery: The bioactive compounds in Shilajit, including fulvic acid and humic acid, may have a positive impact on epigenetic regulation. By influencing the expression of genes, these compounds can support the body’s natural ability to repair and regenerate at the cellular level. This epigenetic modulation is particularly significant for individuals recovering from chronic illnesses, as it can help in resetting and rebooting cellular functions that are crucial for recovery. Synergistic Effects with Other Nutrients: The inclusion of Shilajit standardized to fulvic acid 20% in a supplement regimen can enhance the efficacy of other nutrients and supplements due to its ability to improve nutrient absorption and utilization. This makes it an invaluable component of a holistic approach to health and wellness, particularly for those looking to optimize their nutrient intake and support overall cellular health. Incorporating Shilajit standardized to fulvic acid 20% into a product can offer a range of health benefits, from enhancing nutrient absorption and supporting cellular health to detoxifying the body and potentially aiding in the recovery from chronic illnesses through epigenetic modulation.
Highly Concentrated Form: Aloe Vera 200:1 indicates a highly concentrated form where 1 part of the concentrate is equivalent to 200 parts of fresh Aloe Vera juice. This potency ensures that even small doses in supplements can provide significant health benefits. Digestive Health Support: Aloe Vera is renowned for its soothing and healing properties, particularly for the gastrointestinal tract. It can help in maintaining healthy digestion by supporting the repair and regeneration of the intestinal lining, reducing irritation, and promoting regular bowel movements. The anti-inflammatory properties of Aloe Vera also aid in calming the digestive system, making it beneficial for conditions such as irritable bowel syndrome (IBS) and acid reflux. Immune System Boost: The polysaccharides found in Aloe Vera act as immune modulators, which can help strengthen the body’s immune response. These compounds can stimulate macrophages, which are white blood cells that fight viruses and other pathogens. Aloe Vera also contains a range of antioxidants, including vitamins C, E, and beta-carotene, which can protect the body from oxidative stress and support overall immune function. Nutrient-Rich Composition: Aloe Vera is packed with vitamins, minerals, enzymes, and amino acids that are essential for health. This includes vitamins A, C, and E, which are crucial for immune function, as well as minerals like zinc and selenium that further support immune health. The enzymes present in Aloe Vera can help break down sugars and fats, aiding digestion. Anti-inflammatory and Antimicrobial Properties: Aloe Vera has natural anti-inflammatory and antimicrobial properties, making it beneficial for both internal and topical use. These properties help in reducing inflammation throughout the body, including the digestive system, and can protect against bacterial, fungal, and viral infections. This concentrated Aloe Vera form is especially suitable for dietary supplements aimed at improving digestive health and enhancing immune response, offering a natural and potent solution for maintaining overall well-being.
Bacillus coagulans Butyrate Production: This strain contributes to the production of butyrate in the gut, a short-chain fatty acid essential for maintaining intestinal barrier function and supporting gut health. Digestive Health Benefits: It has been shown to improve symptoms of IBS, including diarrhea and constipation, by modulating the gut flora and enhancing the intestinal barrier. Immune System Support: Bacillus coagulans may help strengthen the immune system by improving gut barrier function, which can prevent pathogens from entering the bloodstream. Potential for Mast Cell Stabilization: While specific research on Bacillus coagulans directly affecting mast cells is limited, its overall benefits for gut health may indirectly support individuals with Mast Cell Activation Syndrome (MCAS) by reducing gut inflammation and possibly influencing systemic immune responses. Influence on Mood and Appetite: By contributing to a healthy gut microbiome, Bacillus coagulans may impact serotonin production, potentially influencing mood and reducing cravings, which could support weight management efforts. Lacticaseibacillus rhamnosus GG Renowned for Gut Health: One of the most studied probiotic strains, known for its ability to survive the acidic stomach environment and colonize the gut effectively. Butyrate Producer: Like Bacillus coagulans, it plays a role in fostering a gut environment that supports the production of beneficial short-chain fatty acids such as butyrate. Support for Immune Health: Lacticaseibacillus rhamnosus GG has been shown to enhance immune defense mechanisms, which may benefit cardiovascular, nervous system, and musculoskeletal health through improved gut-immune system communication. Benefits for MCAS, SIBO, and IBS: This strain has demonstrated efficacy in managing symptoms of SIBO (Small Intestinal Bacterial Overgrowth) and IBS, and its anti-inflammatory properties may benefit individuals with MCAS by stabilizing mast cells and reducing inflammation. Impact on Appetite, Cravings, and Mood: It may help regulate appetite and reduce cravings through its influence on the gut-brain axis, potentially contributing to mood stabilization and supporting weight loss efforts by promoting feelings of fullness and reducing emotional eating.
Saccharomyces Boulardii Probiotic Support: Saccharomyces boulardii is a robust, non-colonizing, non-pathogenic yeast that plays a crucial role as a probiotic. It supports the balance of beneficial gut flora and is often used to maintain and restore the natural flora in the gastrointestinal tract. Gastrointestinal Health: This probiotic is particularly effective in the prevention and treatment of diarrhea associated with antibiotic use, as well as traveler’s diarrhea and diarrhea caused by Clostridioides difficile infections. Its efficacy extends to reducing the duration and severity of these conditions. Immune System Enhancement: Saccharomyces boulardii bolsters the immune system by enhancing intestinal barrier function and modulating immune responses. This support helps in maintaining overall health and combating various gastrointestinal disorders. Anti-Inflammatory Properties: It exhibits anti-inflammatory effects within the gut, which can be beneficial for individuals suffering from inflammatory bowel diseases (IBD), such as Crohn’s disease and ulcerative colitis, by reducing inflammation and promoting healing. Nutrient Absorption: By improving the health of the gut lining, Saccharomyces boulardii enhances the body’s ability to absorb nutrients, which is critical for overall health and well-being. Potential for Allergy and Infection Reduction: Preliminary research suggests that Saccharomyces boulardii may help reduce the risk of certain gut infections and possibly influence allergic responses, though more research is needed to fully understand these effects. Incorporating Saccharomyces boulardii into a dietary supplement regimen can contribute significantly to the maintenance of a healthy gut microbiome, supporting digestive health, and bolstering the immune system. Its wide-ranging benefits make it a valuable component of gut health strategies, particularly for individuals looking to maintain or restore balance to their intestinal flora.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


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